Workpackage #5/5
Modulation the HUFA metabolism by lignans.
The effects of the sesamin, a modulator of the lipid metabolism to mammals, will be investigated on the biosynthesis and the abundance of the HUFA in the white muscle of fish.
This experiment will be realized according to the modelling of the fatty acids metabolism based on the complete physical balance assessments.
To this
end, an experimental n-3 HUFA free diet will be formulated with a-linolenic
(ALA) fatty acid precursor and supplemented with sesamin. The influence
of this supplementation on the ß-oxidation and the bioconversion
of ALA in EPA and DHA will be measured.
2/ Structural characterization of the proteins FADS (FADS1 and FADS2)
